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研究業績

  • 160. CD38/cyclic ADP-ribose system: a new player for oxytocin secretion and regulation of social behaviour.
    Salmina AB, Lopatina O, Ekimova MV, Mikhutkina SV, Higashida H.
    J Neuroendocrinol. 22(5): 380-392, 2010.
  • 159. Oxytocin signal and social behaviour: comparison among adult and infant oxytocin, oxytocin receptor and CD38 gene knockout mice.
    Higashida H, Lopatina O, Yoshihara T, Pichugina YA, Soumarokov AA, Munesue T, Minabe Y, Kikuchi M, Ono Y, Korshunova N, Salmina AB.
    J Neuroendocrinol. 22(5): 373-379, 2010.
  • 158. Oxytocin-induced elevation of ADP-ribosyl cyclase activity, cyclic ADP-ribose or Ca(2+) concentrations is involved in autoregulation of oxytocin secretion in the hypothalamus and posterior pituitary in male mice.
    Lopatina O, Liu HX, Amina S, Hashii M, Higashida H.
    Neuropharmacology. 58(1): 50-55, 2010.
  • 157. Long QT syndrome and associated gene mutation carriers in Japanese children: results from ECG screening examinations.
    Hayashi K, Fujino N, Uchiyama K, Ino H, Sakata K, Konno T, Masuta E, Funada A, Sakamoto Y, Tsubokawa T, Nakashima K, Liu L, Higashida H, Hiramaru Y, Shimizu M, Yamagishi M.
    Clin Sci (Lond). 117(12): 415-424, 2009.
  • 156. Locomotor activity, ultrasonic vocalization and oxytocin levels in infant CD38 knockout mice.
    Liu HX, Lopatina O, Higashida C, Tsuji T, Kato I, Takasawa S, Okamoto H, Yokoyama S, Higashida H.
    Neurosci Lett. 448(1): 67-70, 2008.
  • 155. Genetic analyses of roundabout (ROBO) axon guidance receptors in autism.
    Anitha A, Nakamura K, Yamada K, Suda S, Thanseem I, Tsujii M, Iwayama Y, Hattori E, Toyota T, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya K, Sugihara G, Ouchi Y, Sugiyama T, Koizumi K, Higashida H, Takei N, Yoshikawa T, Mori N.
    Am J Med Genet B Neuropsychiatr Genet. 147B(7): 1019-1027, 2008.
  • 154. Decreased ADP-ribosyl cyclase activity in peripheral blood mononuclear cells from diabetic patients with nephropathy.
    Ohtsuji M, Yagi K, Shintaku-Kubota M, Kojima-Koba Y, Ito N, Sugihara M, Yamaaki N, Chujo D, Nohara A, Takeda Y, Kobayashi J, Yamagishi M, Higashida H.
    Exp Diabetes Res. 2008:897508, 2008.
  • 153. Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system.
    Higashida H, Salmina AB, Olovyannikova RY, Hashii M, Yokoyama S, Koizumi K, Jin D, Liu HX, Lopatina O, Amina S, Islam MS, Huang JJ, Noda M.
    Neurochem Int. 51(2-4): 192-199, 2007.
  • 152. RNA interference screen to identify genes required for Drosophila embryonic nervous system development.
    Koizumi K, Higashida H, Yoo S, Islam MS, Ivanov AI, Guo V, Pozzi P, Yu SH, Rovescalli AC, Tang D, Nirenberg M.
    Proc Natl Acad Sci U S A. 104(13): 5626-5631, 2007.
  • 151. CD38 is critical for social behaviour by regulating oxytocin secretion.
    Jin D, Liu HX, Hirai H, Torashima T, Nagai T, Lopatina O, Shnayder NA, Yamada K, Noda M, Seike T, Fujita K, Takasawa S, Yokoyama S, Koizumi K, Shiraishi Y, Tanaka S, Hashii M, Yoshihara T, Higashida K, Islam MS, Yamada N, Hayashi K, Noguchi N, Kato I, Okamoto H, Matsushima A, Salmina A, Munesue T, Shimizu N, Mochida S, Asano M, Higashida H.
    Nature. 446(7131): 41-45, 2007.
  • 150. Overexpression of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced Ca2+ signalling in rodent NG108-15 neuroblastoma cells.
    Higashida H, Bowden SE, Yokoyama S, Salmina A, Hashii M, Hoshi N, Zhang JS, Knijnik R, Noda M, Zhong ZG, Jin D, Higashida K, Takeda H, Akita T, Kuba K, Yamagishi S, Shimizu N, Takasawa S, Okamoto H, Robbins J.
    Neurosci Res. 57(3): 339-346, 2007.
  • 149. Identification of calreticulin as a marker for phagocytosis of apoptotic cells in Drosophila.
    Kuraishi T, Manaka J, Kono M, Ishii H, Yamamoto N, Koizumi K, Shiratsuchi A, Lee BL, Higashida H, Nakanishi Y.
    Exp Cell Res. 313(3): 500-510, 2007.
  • 148. Bradykinin activates ADP-ribosyl cyclase in neuroblastoma cells: intracellular concentration decrease in NAD and increase in cyclic ADP-ribose.
    Higashida H, Salmina A, Hashii M, Yokoyama S, Zhang JS, Noda M, Zhong ZG, Jin D.
    FEBS Lett. 580(20): 4857-4860, 2006.
  • 147. Induction of tumor necrosis factor-alpha in Schwann cells after gradual elongation of rat sciatic nerve.
    Hagiwara N, Ikeda K, Higashida H, Tomita K, Yokoyama S.
    J Orthop Sci. 10(6): 614-621, 2005.
  • 146. Acetylcholine stimulates cyclic ADP-ribose formation via M1 muscarinic receptors in rat superior cervical ganglion.
    Zhang JS, Jin D, Higashida H.
    Biochem Biophys Res Commun. 335(3): 920-924, 2005.
  • 145. Amplification of depolarization-induced and ryanodine-sensitive cytosolic Ca2+ elevation by synthetic carbocyclic analogs of cyclic ADP-ribose and their antagonistic effects in NG108-15 neuronal cells.
    Hashii M, Shuto S, Fukuoka M, Kudoh T, Matsuda A, Higashida H.
    J Neurochem. 94(2): 316-323, 2005.
  • 144. Synthesis of stable and cell-type selective analogues of cyclic ADP-ribose, a Ca(2+)-mobilizing second messenger. Structure--activity relationship of the N1-ribose moiety.
    Kudoh T, Fukuoka M, Ichikawa S, Murayama T, Ogawa Y, Hashii M, Higashida H, Kunerth S, Weber K, Guse AH, Potter BV, Matsuda A, Shuto S.
    J Am Chem Soc. 127(24): 8846-8855, 2005.
  • 143. Induction of interleukin-6 in dorsal root ganglion neurons after gradual elongation of rat sciatic nerve.
    Osamura N, Ikeda K, Ito T, Higashida H, Tomita K, Yokoyama S.
    Exp Neurol. 195(1): 61-70, 2005.
  • 142. Cyclin-dependent kinase 5 activators p35 and p39 facilitate formation of functional synapses.
    Johansson JU, Lilja L, Chen XL, Higashida H, Meister B, Noda M, Zhong ZG, Yokoyama S, Berggren PO, Bark C.
    Brain Res Mol Brain Res. 138(2): 215-227, 2005.
  • 141. Protein kinase C bound with A-kinase anchoring protein is involved in muscarinic receptor-activated modulation of M-type KCNQ potassium channels.
    Higashida H, Hoshi N, Zhang JS, Yokoyama S, Hashii M, Jin D, Noda M, Robbins J.
    Neurosci Res. 51(3): 231-234, 2005.
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