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研究業績

  • 140. Genes required for Drosophila nervous system development identified by RNA interference.
    Ivanov AI, Rovescalli AC, Pozzi P, Yoo S, Mozer B, Li HP, Yu SH, Higashida H, Guo V, Spencer M, Nirenberg M.
    Proc Natl Acad Sci U S A. 101(46): 16216-16221, 2004.
  • 139. Compound heterozygosity for mutations Asp611-->Tyr in KCNQ1 and Asp609-->Gly in KCNH2 associated with severe long QT syndrome.
    Yamaguchi M, Shimizu M, Ino H, Terai H, Hayashi K, Kaneda T, Mabuchi H, Sumita R, Oshima T, Hoshi N, Higashida H.
    Clin Sci (Lond). 108(2): 143-150, 2005.
  • 138. Draper-mediated and phosphatidylserine-independent phagocytosis of apoptotic cells by Drosophila hemocytes/macrophages.
    Manaka J, Kuraishi T, Shiratsuchi A, Nakai Y, Higashida H, Henson P, Nakanishi Y.
    J Biol Chem. 279(46): 48466-48476, 2004.
  • 137. Probucol aggravates long QT syndrome associated with a novel missense mutation M124T in the N-terminus of HERG.
    Hayashi K, Shimizu M, Ino H, Yamaguchi M, Terai H, Hoshi N, Higashida H, Terashima N, Uno Y, Kanaya H, Mabuchi H.
    Clin Sci (Lond). 107(2): 175-182, 2004.
  • 136. Multiple signal transduction pathways mediated by 5-HT receptors.
    Noda M, Higashida H, Aoki S, Wada K.
    Mol Neurobiol. 29(1): 31-39, 2004.
  • 135. AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists.
    Hoshi N, Zhang JS, Omaki M, Takeuchi T, Yokoyama S, Wanaverbecq N, Langeberg LK, Yoneda Y, Scott JD, Brown DA, Higashida H.
    Nat Neurosci. 6(6): 564-571, 2003.
  • 134. Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells.
    Higashida H, Zhang JS, Mochida S, Chen XL, Shin Y, Noda M, Hossain KZ, Hoshi N, Hashii M, Shigemoto R, Nakanishi S, Fukuda Y, Yokoyama S.
    J Neurochem. 85(5): 1148-1158, 2003.
  • 133. Clinical and electrophysiological characterization of a novel mutation (F193L) in the KCNQ1 gene associated with long QT syndrome.
    Yamaguchi M, Shimizu M, Ino H, Terai H, Hayashi K, Mabuchi H, Hoshi N, Higashida H.
    Clin Sci (Lond). 104(4): 377-382, 2003.
  • 132. Recombinant human serotonin 5A receptors stably expressed in C6 glioma cells couple to multiple signal transduction pathways.
    Noda M, Yasuda S, Okada M, Higashida H, Shimada A, Iwata N, Ozaki N, Nishikawa K, Shirasawa S, Uchida M, Aoki S, Wada K.
    J Neurochem. 84(2): 222-232, 2003.
  • 131. Measurement of adenylyl cyclase by separating cyclic AMP on silica gel thin-layer chromatography.
    Higashida H, Hossain KZ, Takahagi H, Noda M.
    Anal Biochem. 308(1): 106-111, 2002.
  • 130. Characterization of a novel missense mutation E637K in the pore-S6 loop of HERG in a patient with long QT syndrome.
    Hayashi K, Shimizu M, Ino H, Yamaguchi M, Mabuchi H, Hoshi N, Higashida H.
    Cardiovasc Res. 54(1): 67-76, 2002.
  • 129. Cyclic ADP-ribose as a second messenger revisited from a new aspect of signal transduction from receptors to ADP-ribosyl cyclase.
    Higashida H, Hashii M, Yokoyama S, Hoshi N, Chen XL, Egorova A, Noda M, Zhang JS.
    Pharmacol Ther. 90(2-3): 283-296, 2001.
  • 128. Overexpression of rat neuronal calcium sensor-1 in rodent NG108-15 cells enhances synapse formation and transmission.
    Chen XL, Zhong ZG, Yokoyama S, Bark C, Meister B, Berggren PO, Roder J, Higashida H, Jeromin A.
    J Physiol. 532(Pt 3): 649-659, 2001.
  • 127. Signal transduction from bradykinin, angiotensin, adrenergic and muscarinic receptors to effector enzymes, including ADP-ribosyl cyclase.
    Higashida H, Yokoyama S, Hoshi N, Hashii M, Egorova A, Zhong ZG, Noda M, Shahidullah M, Taketo M, Knijnik R, Kimura Y, Takahashi H, Chen XL, Shin Y, Zhang JS.
    Biol Chem. 382(1): 23-30, 2001.
  • 126. Cyclic ADP-ribose as a potential second messenger for neuronal Ca2+ signaling.
    Higashida H, Hashii M, Yokoyama S, Hoshi N, Asai K, Kato T.
    J Neurochem. 76(2): 321-331, 2001.
  • 125. Cyclooxygenase-2 stimulates production of amyloid beta-peptide in neuroblastoma x glioma hybrid NG108-15 cells.
    Kadoyama K, Takahashi Y, Higashida H, Tanabe T, Yoshimoto T.
    Biochem Biophys Res Commun. 281(2): 483-490, 2001.
  • 124. Angiotensin II stimulates cyclic ADP-ribose formation in neonatal rat cardiac myocytes.
    Higashida H, Zhang J, Hashii M, Shintaku M, Higashida C, Takeda Y.
    Biochem J. 352 Pt 1: 197-202, 2000. Erratum in: Biochem J 354(Pt 3): 727, 2001.
  • 123. Both linopirdine- and WAY123,398-sensitive components of I K(M,ng) are modulated by cyclic ADP ribose in NG108-15 cells.
    Higashida H, Brown DA, Robbins J.
    Pflugers Arch. 441(2-3): 228-234, 2000.
  • 122. Membrane-bound form of ADP-ribosyl cyclase in rat cortical astrocytes in culture.
    Hotta T, Asai K, Fujita K, Kato T, Higashida H.
    J Neurochem. 74(2): 669-675, 2000.
  • 121. cADP-ribose potentiates cytosolic Ca2+ elevation and Ca2+ entry via L-type voltage-activated Ca2+ channels in NG108-15 neuronal cells.
    Hashii M, Minabe Y, Higashida H.
    Biochem J. 345 Pt 2: 207-215, 2000.
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